Scientists discover new genetic variations in neuroblastoma - Charité - Universitätsmedizin Berlin Press Release:Malignant cells can 'learn' how to defend themselves against specific treatments – this also holds true for neuroblastoma and solid tumors emerging during childhood. Genetics studies using next-generation sequencing have now made it possible for a group of researchers working with pediatric oncologists at the Charité – Universitätsmedizin Berlin to gain new insights into the genetic makeup of tumors. In the current edition of the professional journal Nature Genetics*, the scientists outline the related molecular characteristics ─ so-called signatures that elicit changes in the tumor and that are resistant to current therapeutic options.
Cure rates as high as 80% can now be reached for the treatment of some cancers in children and adolescents, and is indeed a major medical achievement. Tumors that return in a relapse, however, are a different story. Treatment options remain…
