Using Computational Modelling to Understand Large-Scale Networks and Circuit Dysfunctions in Schizophrenia

The project "Using Computational Modeling to Understand Large-Scale Networks and Circuit Dysfunctions in Schizophrenia," led by Peter Uhlhaas, Professor of Early Detection and Early Intervention of Mental Illness at Charité - Universitätsmedizin Berlin, is investigating the neural basis of schizophrenia. The focus is on the question of what role changes in certain neurotransmitter systems have in the development of the disease. Since the causes of schizophrenic disorders are still not sufficiently understood, treatment is also limited: While hallucinations, for example, can be reduced by medication, other common accompanying symptoms such as lack of drive, concentration and memory problems of patients remain difficult to treat. In order to be able to better treat schizophrenia in the future, Uhlhaas, in collaboration with a team from the Technical University, is striving for a sound understanding of the biological mechanisms of the disease. To this end, he is using neuro-imaging methods in combination with an innovative brain simulation platform that allows electrophysiological data to be traced back to the underlying neuronal circuits and neurotransmitter systems involved.


Funding period: 09/2021 - 08/23

Prof. Dr. Peter J. Uhlhaas
Charité - Universitätsmedizin Berlin
KJP Forschung
Augustenburger Platz 113359 Berlin
Phone: +49 30 450 516 193

Applicant: Charité - Universitätsmedizin Berlin