Sara Samadzadeh, Clinician Scientist (Postdoc) in the research team of Chotima Böttcher within the Clinical Immunology group led by Professor Friedemann Paul at the Experimental and Clinical Research Center of Charité and the Max Delbrück Center for Molecular Medicine, investigates multiple sclerosis (MS) and related neuroinflammatory diseases. These chronic disorders of the central nervous system are characterized by highly individualized symptoms and disease courses that are difficult to predict.
The project aims to advance diagnostics and therapy through precision medicine approaches. To this end, multidimensional patient data – ranging from clinical findings and imaging to fluid biomarkers, multi-omics and genetic profiles, as well as gut microbiome information and lifestyle factors – will be systematically collected and integrated. Using artificial intelligence and advanced analytical methods, the team seeks to identify patterns in these extensive datasets and develop models that detect early disease signals, predict disease trajectories, and support personalized treatment decisions. In doing so, the project aims to improve understanding of why MS and related conditions affect patients so differently, ultimately enabling earlier and more accurate diagnostics and more effective, individually tailored care for MS and other neuroinflammatory diseases.