At Charité - Universitätsmedizin Berlin, T cells modified with T cell receptors are being used for the first time to treat patients with multiple myeloma, one of the most common bone and bone marrow tumours. In this project associated with the clinical study, the effect of T-cell therapy on the destruction of tumour cells in the bone marrow of mice is being investigated in order to understand and overcome the causes of recurrences, i.e. the recurrence of tumours. Innovative imaging techniques such as long-term analyses at single cell level and 3-photon microscopy in the bone marrow are being used. The research project by Anja Hauser-Hankeln (Professor of Immunology, Charité), Matthias Leisegang (Professor of T-cell therapy, Charité) and Raluca Niesner (Professor of Biophysics in the Department of Veterinary Medicine, FU Berlin) will enable the processes involved in the T-cell-mediated destruction of tumour cells to be studied in real time in the bone marrow in order to pave the way for the development of even more effective T-cell therapies in the future.
Funding period: 09/2020 - 09/2023
Contact:
Prof. Dr. Med. Vet. Anja Erika Hauser-Hankeln
Email: anja.hauser-hankeln@charite.de
Applicant: Charité - Universitätsmedizin Berlin
Partner: Freie Universität Berlin